ABSTRACT

Cancer and lifestyle interventions in immunity – does it help?

Prof. Dr. Grzegorz Dworacki, Chair and Department of Clinical Pathomorphology and Immunology, Poznan University of Medical Sciences, Poznan (Poland)

Cancer in the systemic disease is not only a tumor but is also where immune system failed to provide an efficient immunosurveillance. The tumor microenvironment contains large number of tumor infiltrating lymphocytes, but they are dying even before being able to recognize tumor. There is a growing number of evidence that lifestyle interventions can support immune functions what may prevent cancer and support cancer patients. Physical activity and stretching, decreases level of endogenous immunosuppressive factors as e.g. TGF-beta; there are number of antistress technics promoting lymphocytes survival. Healthy circadian is the key factor for proper lymphocytes circulation what provides proper lymphocyte education an activation; microbiota is a key factor for providing antigen biodiversity which is important for a correct activation and immunotolerance balance.