¹University of Missouri, Columbia, United States, ²Washington University, St. Louis, United States, ³University of Hamburg, Columbia, United States

¹Roche-CHUS Joint Unit. Translational Medical Oncology Group, Oncomet. Health Research Institute of Santiago de Compostela (IDIS), Santiago De Compostela, Spain, ²CIBERONC, Centro de Investigación Biomédica en Red Cáncer, Madrid, Spain, ³Translational Medical Oncology Group, Oncomet. Health Research Institute of Santiago (IDIS), University Hospital of Santiago de Compostela (SERGAS)., Santiago de Compostela, Spain, ⁴Department of Oncology, Complexo Hospitalario Universitario de Santiago de Compostela (SERGAS), Santiago de Compostela, Spain

¹Department of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ²University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ³Mildred Scheel Cancer Career Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁴Center for Experimental Medicine, Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁵Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁶Molecular Skeletal Biology Laboratory, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

¹Division of Genetics, Cell and Developmental Biology, Department of Biology, University of Patras,  Greece, ²Clinical and Molecular Oncology Laboratory, Division of Oncology, Department of Medicine, Medical School, University of Patras, Greece, ³Hellenic Oncology Research Group (HORG), Athens, Greece, ⁴Department of Medical Oncology, General University Hospital of Larissa, Greece

¹Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy, ²Melanoma Oncology Unit, Veneto Institute of Oncology, IOV-IRCCS, Padova, Italy, ³Department of Surgery, Oncology and Gastroenterology, Oncology Section, University of Padova, Padova, Italy, ⁴Familiar Cancer Clinic and Oncoendocrinology, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy, ⁵*These authors contributed equally to this work,  ⁶The author died prior to the submission of this abstract. This is one of her last works.

¹Department of Obstetrics and Gynecology, University Hospital and Medical Faculty of the Heinrich-Heine University Duesseldorf, Düsseldorf, Germany, ²Division "Personalized Tumor Therapy", Fraunhofer Institute for Toxicology and Experimental Medicine, Regensburg, Germany

¹Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany, ²Institute of Tumor Biology, University Hospital Hamburg-Eppendorf, Hamburg, Germany, ³II. Medical Clinic and Polyclinic (Oncology), University Hospital Hamburg-Eppendorf, Hamburg, Germany

¹Department of Gynecology and Obstetrics, Heinrich Heine University Duesseldorf, Duesseldorf, Germany, ²Department of Gynecology and Obstetrics, University Hospital Hamburg-Eppendorf, Hamburg, Germany, ³Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany, ⁴Medical Faculty, Heinrich Heine University Duesseldorf, Duesseldorf, Germany, ⁵Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, ⁶Department of Gynecology and Obstetrics, University Hospital Ulm, Ulm, Germany, ⁷Department of Gynecology and Obstetrics, University Hospital Tuebingen, Tuebingen, Germany, ⁸Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg , Germany, ⁹National Center for Tumor Diseases and Department of Gynecology and Obstetrics, University Hospital Heidelberg, Heidelberg, Germany, ¹⁰Department of Gynecology and Obstetrics, University Hospital Essen-Duisburg, Essen, Germany, ¹¹Onkologische Schwerpunktpraxis Leer, Leer, Germany, ¹²Department of Gynecology and Obstetrics, University Hospital Dresden, TU Dresden, Dresden, Germany, ¹³Department of Gynecology and Obstetrics, University Hospital Charité, Berlin, Germany

¹National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, ³Helmholtz-Zentrum Dresden – Rossendorf (HZDR), Dresden, Germany, ⁴Helmholtz-Zentrum Dresden – Rossendorf, Institute of Radiooncology – OncoRay, Dresden, Germany, ⁵OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, ⁶Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, ⁷German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁸Department of Gynecology and Obstetrics, Heinrich-Heine-University of Düsseldorf, Dresden, Germany, ⁹denovoMATRIX GmbH, Dresden, Germany, ¹⁰German Cancer Research Center (DKFZ), Heidelberg, Germany, ¹¹Department of Experimental Surgical Oncology, University Hospital Düsseldorf, Düsseldorf, Germany, ¹²Dept. for Innovative Methods of Computing, Center of Information Services and High-Performance Computing (ZIH), Technische Universität Dresden, Dresden, Germany, ¹³Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Germany

¹Division of Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, United States, ²Division of Early Drug Development for Innovative Therapies, IEO, European Institute of Oncology IRCCS, Milano, Italy, ³Department of Medical Oncology, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano, Italy

¹Department of Obstetrics & Gynecology, University Hospital Ulm, Ulm, Germany, ²Institute of Pathology, University Hospital Ulm, Ulm, Germany, ³Department of Gynecology and Obstetrics, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany, ⁴Department of Gynecology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁵Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

¹Laboratory of Rare Circulating Human Cells – University Medical Center of Montpellier, France, ²CREEC/CANECEV, MIVEGEC (CREES), Université de Montpellier, CNRS, IRD, Montpellier, France, ³Department of Medical Oncology, Institut du Cancer Montpellier, Montpellier University, Montpellier, France, ⁴Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Montpellier University, Montpellier, France, ⁵Biometrics Unit, Institut du Cancer Montpellier, Montpellier University, Montpellier, France, ⁶Biopathologie et Génétique des Cancers, Institute d’Analyse Médicale Imagenome, Inovie, Montpellier, France

¹Massachusetts General Hospital, Harvard Medical School, Boston, United States

¹Department of Urology, University Hospital Münster, Germany, ²Department of Bioinformatics, University Hospital Münster, Germany, ³Department of Urology, University Hospital Augsburg, Germany

¹University of Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom, ²Cambridge University Hospital NHS Foundation Trust and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, United Kingdom, ³University of Cambridge, MRC Biostatistics Unit, Cambridge, United Kingdom, ⁴These authors contributed equally.

^-2Department of Surgery (A), Medical Faculty, Heinrich-Heine University and University Hospital Duesseldorf, Duesseldorf, Germany, ²Department of Obstetrics and Gynecology, Medical Faculty, Heinrich-Heine University and University Hospital of Duesseldorf, Duesseldorf, Germany, ³Institute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University and University Hospital Duesseldorf, Duesseldorf, Germany

¹Medical Cell BioPhysics, Univeristy of Twente, Enschede, The Netherlands, ²Menarini Silicon Biosystems, Bologna, Italy, ³Heinrich-Heine University Düsseldorf, Düsseldorf, Germany, ⁴University of Groningen and University Medical Center Groningen, Groningen, The Netherlands, ⁵Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg

¹Ludwig-Maximilians-Universität München, Garching, Germany, ²Max-Planck-Institut für Quantenoptik, Garching, Germany, ³Center for Molecular Fingerprinting Research Nonprofit LLC, Budapest, Hungary

¹Department of Medical Cell BioPhysics, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands, ²Department of Medical Oncology, Erasmus MC Cancer Institute, University Medical Center , Rotterdam, The Netherlands

¹Department of Translational Molecular Medicine, Div. Molecular Oncology, John Wayne Cancer Institute, Santa Monica, USA, ²HaimaChek Inc., Santa Monica, USA, ³Invicol GmbH, Berlin, Germany, ⁴Biofluid Mechanics Lab, Charité Universitätsmedizin Berlin, Berlin, Germany

¹University Of Twente, Enschede, The Netherlands, ²KIST Europe, Saarbrücken, Germany 

¹Institut Curie, Department of Oncology, Paris and Saint-Cloud, France, ²Circulating Tumor Biomarkers Laboratory, Inserm CIC-BT 1428, Institut Curie, PSL Research University, Paris, France, ³Institut Curie, Department of Genetics, Paris, France, ⁴SAGA Diagnostics, Lund, Sweden

¹Division of Cancer Genome Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany, ²Translational Lung Research Center Heidelberg, German Center for Lung Research (DZL), Heidelberg, Germany, ³Department of Oncology, Thoraxklinik and National Center for Tumor Disease (NCT) at Heidelberg University Hospital, Heidelberg, Germany, ⁴Bioinformatics and Omics Data Analytics, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁵Medical Faculty, Heidelberg University, Heidelberg, Germany, ⁶Lung Clinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany, ⁷Translational Research Unit, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany, ⁸Institute of Pathology, Heidelberg University, Heidelberg, Germany, ⁹German Cancer Consortium (DKTK), Germany

¹MGZ - Medical Genetics Center, Munich, Germany, ²Pettenkofer School of Public Health, Munich, Germany, ³Institute for Medical Information Processing, Biometry, and Epidemiology –IBE, LMU Munich, Munich, Germany, ⁴Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany, ⁵Department of General, Visceral and Thorax Surgery, Klinikum Ingolstadt, Germany, ⁶Department of General, Visceral, Vascular and Transplant Surgery, University Hospital Munich, Ludwig-Maximilians University of Munich, Campus Großhadern, Munich, Germany, ⁷Department of General, Visceral, Thoracic and Endocrine Surgery, Klinikum Garmisch-Partenkirchen, Teaching Hospital, Ludwig Maximilian University Munich, Garmisch-Partenkirchen, Germany, ⁸Department of Haemaotology, Oncology and Palliative Medicine, Vivantes Klinikum Neukoelln, Berlin, Germany, ⁹Department of Oncology, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany, ¹⁰Department of Oncology and Hematology, Barmherzige Brüder, Klinikum St. Elisabeth, Straubing, Germany

¹University Medical Center Hamburg-Eppendorf, Hamburg, Germany

¹Analysis of Circulating Tumor Cells Lab, Department of Chemistry, University of Athens, Greece, ²Laboratory of Τumor Cell Biology, School of Medicine, University of Crete, Greece, ³Division of Genetics, Cell and Developmental Biology, Department of Biology, University of Patras, Greece, ⁴Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 22455 Hamburg, Germany, ⁵Department of Gynecology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁶Oncology Unit, 2nd Department of Internal Medicine, Attikon University Hospital, Haidari, Greece, ⁷Department of Medical Oncology, University General Hospital of Heraklion, Crete, Greece, ⁸Breast Surgery Department, Euroclinic, Athens, Greece

¹Translational Medical Oncology Group (Oncomet), Health Research Institute of Santiago de Compostela (IDIS), University Hospital of Santiago de Compostela (SERGAS), Trav. Choupana s/n, 15706, Santiago De Compostela, Spain, ²Biomedical Research Group in Gynecology, Vall d’Hebron Research Institute (VHIR), Universitat Autónoma de Barcelona, 119-129 Pg. Vall d’Hebron, 08035, Barcelona, Spain, ³Department of Gynecology, University Hospital of Santiago de Compostela (SERGAS), Trav. Choupana s/n, 15706, Santiago de Compostela, Spain, ⁴Foundation MD Anderson International, C/Gómez Hemans 2, 28033, Madrid, Spain, ⁵Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)., Madrid, Spain, ⁶Department of Pathology, University Hospital of Santiago de Compostela (SERGAS), Trav. Choupana s/n, 15706, Santiago de Compostela, Spain