Preliminary Scientific Program

DAY 1 • Sunday, 9 February 2020
• Room: National A & B (Main Hall) •

07:00am - 6:00pm  REGISTRATION
7:30am - 12:30pm WORKSHOP
Hands-on MpMRI interpretation and MRI-TRUS fusion focal targeted therapy teaching course
Chairs: Rajan Gupta (USA), Ardeshir Rastinehad (USA), Arvin George (USA)
Room:National A & B (Main Hall)
7:30am - 8:10am Segment 1: MRI Interpretation

MRI Course Director: Ardeshir Rastinehad (USA)
MRI Course Instructors: Peter Choyke (USA), Ismail Baris Turkbey (USA), Bradford Wood (USA), Peter Pinto (USA), John Feller (USA), Arnauld Villers (France), Rajan Gupta (USA)

> Introduction - Ardeshir Rastinehad (USA)
> MRI Structured Reporting - Ardeshir Rastinehad (USA)
> MRI Basics for a Urologist - Rajan Gupta (USA)
> MRI Pitfalls - Ismail Baris Turkbey (USA)
8:10am - 9:30am Workshop
(i). Lesion location via Structured Reporting

Chairs: Peter Choyke (USA), John Feller (USA)
(ii). Identify Lesions, Mark ROI of Lesion, Segment Prostate
Instructors: Peter Pinto (USA), Rajan Gupta (USA), Ardeshir Rastinehad (USA), Arvin George (USA), Jochen Walz (France), Fernando Bianco (USA), Mark Emberton (United Kingdom), Andre Luis de Castro Abreu (USA)
9:30am - 10:30am Segment 2: Fusion targeting / Case Setup - Workflows
Instructors:  Arvin George (USA), Peter Pinto (USA), Ardeshir Rastinehad (USA), Osamu Ukimura (Japan), Andre Luis de Castro Abreu (USA), Fernando Bianco (USA), Mark Emberton (United Kingdom)
10:30am - 10:45am Coffee Break
10:45am - 12:30pm Segment 3: Platforms and Performance of Focal Therapy - Talk with the Experts
> HIFU - Mark Emberton (United Kingdom)
> HIFU - Rafael Sanchez-Salas (France)
> Cryoblation - Thomas Polascik (USA)
> Irreversible Electroporation - Jean De La Rosette (Netherlands)
> Photodynamic Therapy - Andre Luis de Castro Abreu (USA)
> MRI guided laser ablation - John Feller (USA)
Q and A
12:30pm - 1:30pm Lunch
1:30pm - 3:30pm Workshop | Next Generation solution for today's prostate cancer Management
(Click here to view further information)
Room: East Room
1:30pm - 3:30pm Prostate Consensus 1: Coming off active surveillance: Focal Therapy’s sweet spot? (closed session / by invitation only)
Chairs: Thomas Polascik (USA)          
  Closed session - participation by invitation only  Room: Ashlawn North
1:30pm - 3:30pm Prostate Consensus 2: Biomarkers in prostate focal therapy  (closed session / by invitation only)
Chairs: Rafael Sanchez Salas (France)
   Closed session - participation by invitation only
 Room: Ashlawn South
1:30pm - 3:30pm Poster session 1: Diagnostic / Imaging
Moderator: Peter Choyke (USA)
Room: Monticello East
1:30pm - 3:30pm Poster session 2: Focal Therapies
Room: Monticello West
3:30pm - 4:00pm Coffee break
4:00pm - 5:45pm Flagship Video Session: “This is how I do it”
Room: National A & B (Main Hall)
Chairs: Arvin George (USA), Daniel Rukstalis (USA)
1 "Trojan Horse" model for prostate cancer treatment using stromal vascular fraction (SVF) and oncolytic virus - John Feller (USA)
2 Robotic Approach to MRI-targeted + saturation biopsy - Kae Jack Tay (Singapore)
3 MRI Fusion Guided Prostate
Partial Gland Cryoablation Aided by a Virtual 3D Modeling: A step by step illustration - Ezequiel Becher (USA)
4 Focal Cryoablation of the prostate - Osamu Ukimura (Japan)
5 Perineologic transperineal prostate biopsy - Mike Gorin (USA)
6 Epigenetics and mapping - TBD - Dave Crawford (USA)
7 Boiling histotripsy for FT - Vera Khokhlova (USA) (UW)
8 CEUS for evaluation and follow up of FT - Andre Luis de Castro Abreu (USA)
9 Cryoablation of renal masses and outcome in pT1b tumors - Jochen Walz (France)
6:45pm - 7:00pm Welcome & Networking Reception

DAY 2 • Monday, 10 February 2020
• Room: National A & B (Main Hall) •

7:00am - 8:00am Industry Breakfast Symposium 
(Click here to view further information)
8:00am - 8:45am Epidemiology and Active Surveillance
   Moderators: Peter Carroll (USA), Arnauld Villers (France)
> Intelligent prostate cancer screening: Defining the need for precision diagnostics - Sigrid Carlsson (USA)
> Is AS after FT the same as de novo AS? - Laurie Klotz (Canada)
> Active Surveillance as an Alternative to Treatment for Small Renal Tumors - Phillip Pierorazio (USA) (JHH)
8:45am - 9:45am Patient Selection for Focal Therapy
   Moderators:  Daniel Rukstalis (USA), Georg Salomon (Germany), Kae Jack Tay (Singapore)
  > Focal therapy for intermediate-high risk prostate cancer: expanding indications - Andre Luis de Castro Abreu (USA)
> Rationale for the high-risk primary patient - Mark Emberton (UK)
> Rationale for salvage focal therapy - Aaron Katz (USA)
> PT selection for renal ablation - Thomas Jarrett (USA)
> Tissue-based genomic classifiers for prostate cancer: can they help identify candidates for AS or FT [Oncotype, Prolaris, Decipher] is there an impact on outcomes? - Peter Carroll (USA)
9:45am - 10:15am Debate presentations: Can focal therapy replace prostatectomy in men with a localized, clinically significant lesion and a negative standard biopsy?
  Moderators: Herb LeporAndre Luis de Castro Abreu (USA), Laurie Klotz (Canada)
Mark Emberton (UK): PRO
Peter Carroll (USA): CON
10:15am - 10:45am
Coffee break
10:45am - 11:45am Biopsy Panel
  Moderator: Peter Ka-Fung Chiu (Hong Kong), David Crawford (USA), Soroush Rais-Bahrami (USA)

> Patient Selection: How many bxs are minimally necessary vs too many? - Kae Jack Tay (Singapore)
> A Negative Fusion Biopsy. What did I miss and what is the next step? - Peter Pinto (USA)
> Renal Mass Biopsy: an underutilized technique. For whom and how? - Timothy McClure (USA)
> Targeted biopsy for planning FT - Leonard Marks (USA)
> Surveillance after FT: How to define success after focal therapy, MR targeted only vs MR Targeted and Standard Biopsy vs Imaging only - Herb Lepor (USA)
11:45am - 12:15pm Adjuncts and Immunotherapy as the holy grail
  Chair: Phillip Pierorazio (USA), Rafael Sanchez Salas (France), Mark Emberton (United Kingdom)
  Promise of Adjunct Immunotherapy - Kwanghee Kim (USA)
Combinatorial strategies to optimize Freezing insult - John Baust (USA)
12:15pm - 1:15pm Industry Lunch Symposium
(Click here to view further information)
1:15pm - 1:30pm How to start a focal therapy program for the General Urologist
  Moderators: Fernando Bianco (USA), Leonard Marks (USA)
> Screening, Staging and Follow up - Ardeshir Rastinehad (USA)
> Focal Therapy Modality Selection, First Steps - Arvin George (USA
1:30pm - 2:00pm Imaging Panel 1: Engineering and Imaging News Panel
  Moderators: Shyam Natarajan (USA), Kathy Nightingale (USA), Vera Khokhlova (USA)
> Molecular Imaging to Aid in the Histologic Characterization of Small Renal Tumors - Mike Gorin (USA)
> Computer Aided Detection of mpMRI - Anant Madabhushi (USA) [Case western]
> Artificial Intelligence based margin prediction - Shyam Natarajan (USA)
2:00pm - 2:40pm Imaging Panel 2: Multiparametric MRI
  Moderators: Rajan Gupta (USA), Peter Pinto (USA), Leonard Marks (USA)
> PIRADS 3 - worthy of targeted biopsy or low yield? - Peter Choyke (USA)
> mpMRI to detect recurrence - case presentations - Ismail Baris Turkbey (USA)
> mpMRI - Is the next step to improve the technology or the community expert reader - Rajan Gupta
2:40pm - 3:30pm mpUS and High Frequency Ultrasound
  Moderators: Christian Pavlovich (USA), Georg Salomon (Germany), Laurence Klotz (Canada)
> Performance of micro-ultrasound imaging for diagnosis and treatment of PCa - David Crawford (USA)
> Multi-parametric ultrasound for targeting prostate cancer procedures - Kathy Nightingale (USA)
> Validating High frequency ultrasound with pathologic correlation - Jochen Walz (France)
> Using high frequency US and targeted biopsy platforms for FT - Daniel Rukstalis (USA)
> Proposed New End-point for Localized, Low-risk Prostate Cancer Trials: Progression-free and Radical Treatment-Free Survival – Inderbir Gill (USA)
3:30pm - 4:00pm Coffee break
4:00pm - 4:40pm Pathology, serum markers and genomic classifiers
  Moderators: David Crawford (USA)
Prostate Consensus report 2020 - Thomas J. Polascik (USA), Wei Phin Tan (USA)
> Serum and urine biomarkers for prostate cancer [PHI, 4k, SelectMDx]: where do they integrate with MRI - Timothy McClure (USA)
> How the genetics of renal cancers impacts clinical behavior and treatment decisions - Marston Linehan (USA) - NCI
> Interpreting prostate biopsies after focal therapy - Maria Merino (USA)
4:40pm - 5:30pm “From My Perspective”
  Moderator: Herb Lepor (USA), Daniel Rukstalis (USA)
> Why we need a Focal Therapy Society - Thomas Polascik (USA)
> How to engage industry to partner with academics to impact the field - Jean de la Rosette (Netherlands)
> Incorporating patient preference perspectives for novel PCa therapies - Charles Viviano (USA)

DAY 3 • Tuesday, 11 February 2020
• Room: National A & B (Main Hall) •

7:15am - 7:30am Consensus 1 & 2 - Presentation of consensus II results
   Moderators: Thomas Polascik (USA), Pilar Laguna (Netherlands)
7:30am - 9:45am Trial updates: Latest prostate and kidney FT outcomes
Moderators:  Jochen Walz (France), Aaron Katz (USA), Kae Jack Tay (Singapore)
> IRE Prostate - Jean De la Rosette (Netherlands)
> Gold Nanoparticles Multi-Institutional Trial- NCT02680535 - Art Rastinehad (USA)
> Boiling histotripsy for FT - Vera Khokhlova (USA) (UW)
> Fusion guided VLL Microwave
> Focal Radiotherapy - Soroush Rais-Bahrami (USA)
> Focal Brachytherapy - Danny Song (USA)
> Laser: Phase II outpatient MR-guided laser focal therapy: 10 yr interim results – John Feller (USA)
> Laser: FLA out of bore - Shyam Natarajan (USA)
> TACT study and MRI-guided Focal TULSA - Christian Pavlovich (USA)

Moderators: Jean De La Rosette (Netherlands), Ardeshir Rastinehad (USA)
> Partial anterior prostatectomy- Arnauld Villers (France)
> Prostate Cryoablation - 20 year experience TIPS and Tricks - Aaron Katz (USA)
> HIFU – European experience update - Rafael Sanchez Salas (France)
> Renal cryo - Pilar Laguna (Netherlands)
> Renal IRE and RFA – Jeffrey Cadeddu (USA)
> Radio-guided surgery - Georg Salomon (Germany)

9:45am - 10:15am Coffee break
10:15am - 10:45am Office-Based Procedures
  Moderator: Osamu Ukimura (Japan), Peter Ka-Fung Chiu (Hong Kong)
> Are we likely to acquire a code for fusion biopsy? - Norman Smith (USA)
> What can be done/coded in the office?
> Office Based MRI Fusion Targeted Prostate Cryoablation: 5 year outcomes with Tips and Tricks - Fernando Bianco (USA)
10:45am - 11:15am Focal Therapy Follow-up
  Moderators: Jeffrey Cadeddu (USA), Peter Ka-Fung Chiu (Hong Kong)
  > Surveillance after focal therapy of the prostate (Japan Consensus) - Amir Lebastchi (USA)
> Defining radiologic success/failure after renal/prostate FT - Ismail Baris Turkbey (USA)
> How reliable is MRI for follow-up? - Peter Pinto (USA)
> How reliable is imaging vs biopsy after renal ablation and how to define success? - Bradford Wood (USA)
11:15am - 12:30pm Round table: “It didn’t work. Treatment of recurrence with Salvage therapy: which option?”
  Moderator: Danny Song (USA), Fernando Bianco (USA), Arnauld Villers (France)

> When is additional FT reasonable vs surgery? - Jeffrey Cadeddu (USA)
> When is additional FT reasonable? - Osamu Ukimura (Japan)
> Salvage surgical treatment after FT prostate failure - Rafael Sanchez Salas (France)
12:30pm Closing Ceremony

Closed session - participation by invitation only